Gold Suppliers > Hubei new DE sheng material science and technology co., LTD. > T cell Immunoreceptor with Ig and ITIM domains
- Search Product
-
-
- Region :Other Chemicals
- Tel : 86-18971041571
- Fax :
- Email :vickyzhao@whdschem.com
- URL :
- Details for China T cell Immunoreceptor with Ig and ITIM domains
-
T cell Immunoreceptor with Ig and ITIM domains
Category : Other Chemicals
CAS NO : EC NO : MF : MW : Product description : TIGIT (T cell Immunoreceptor with Ig and ITIM domains), also known as Vstm3, Vsig9, WUCAM, is a newly discovered immunosuppressive co stimulator molecule with a molecular weight of 30-34kD. It is expressed on T cells and NK cells and has immunoglobulin like domains, transmembrane domains, and immunoglobulin tyrosine inhibitory motifs (ITIMs), hence the name TIGIT. TIGIT is a type I transmembrane protein and belongs to the Ig superfamily CD28 member. Human TIGIT has 244 amino acids, including a 21aa signal peptide, a 120aa extracellular domain (containing V-type immunoglobulin like domains and two potential N-terminal glycosylation sites), a 21aa transmembrane region, and an 82aa cytoplasmic region carrying ITIM motifs. TIGIT is an emerging inhibitory receptor shared by NK and T cells, with high affinity for the highly expressed PVR (CD155) in tumor cells. It directly inhibits the killing effect of NK and T cells on tumor cells through the ITIM region of TIGIT, similar to the inhibitory effect of CTLA-4 on T cells. Uses : Antigen antibody Synonyms : no data
- more>>Other Products
-
- • Biological buffer 3- [N, N-di (hydroxyethyl) amino] -2-hydroxypropanesulfonic acid DIPSO
- • Luminol Sodium Salt
- • 4-Aminophthalhydrazide
- • acridinium ester DMAE-NHS
- • acridinium ester NSP-DMAE-NHS
- • Acridine hydrochloride NSP-SA
- • Acridine hydrochloride NSP-SA-NHS
- • NSP-SA-ADH
- • acridinium ester ME-DMAE-NHS TOOS; 3-(N-Ethyl-3-Methylanilino)-2-Hydroxypropanesulfonic Acid Sodium Salt
- • TOPS; Sodium 3-(N-Ethyl-3-Methylanilino)Propanesulfonate; N-Ethyl-N-Sulfopropyl-M-Toluidine Sodium Salt
- • ADOS Sodium 3-(Ethyl(3-Methoxyphenyl)Amino)-2-Hydroxypropane-1-Sulfonate Dihydrate
- • ADPS N-Ethyl-N-(3-Sulfopropyl)-3-Methoxyaniline Sodium Salt
- • ALPS N-Ethyl-N-(3-Sulfopropyl)Aniline Sodium Salt; Sodium 3-(Ethyl(Phenyl)Amino)Propane-1-Sulfonate; Sodium
- • DAOS; Sodium 3-((3,5-Dimethoxyphenyl)(Ethyl)Amino)-2-Hydroxypropane-1-Sulfonate
- • HDAOS; N-(2-Hydroxy-3-Sulfopropyl)-3,5-Dimethoxyaniline Sodium Salt
- • MADB N,N-Bis(4-Sulfobutyl)-3,5-Dimethylaniline Disodium Salt
- • MAOS N-Ethyl-N-(2-Hydroxy-3-Sulfopropyl)-3,5-Dimethylaniline Sodium Salt Monohydrate
- • DAB 3,3',4,4'-Biphenyltetramine Tetrahydrochloride